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| Encoll's Product Lines |
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EnColl's
Collagen Technology
EnColl's technology is
based on a Two-step enzyme Treatment Process (TTP) for
the modification and purification of Type-I collagen
resulting in 99% pure Type-I collagen. EnColl's
Type-I collagen is the purest, least immunogenic and
highly bioactive, making it the ideal choice for the
treatment, therapy and regeneration of tissue system(s) as it applies to various medical applications.
Papain, an enzyme extracted
from papaya, is known to break the cleavage sites neighboring
the disulfide bonds of cysteine. Papain has also been
reported to have a lytic (destructive) effect of elastin
and bound antibodies the contaminants that are difficult
to remove from purified collagen (Coulson, Biochim.
Biophys. Acta 237:378, 1971; and Smith et al., Nature
198:1311-2, 1963 ).
After the purification process, EnColl's collagen is
further bioactivated by varied degrees of controlled
modification of phosphorylation. Purified collagen can
be chemically-modified by covalently binding phosphates
to hydroxyl groups of hydroxylated amino acids. This
reaction likely involves covalent bonding of phosphate
to hydroxyl group of serine, tyrosine and/or threonine,
hydroxylysine and hydroxyproline. The reaction is controllable
to achieve different degrees of bioactivity for varied
applications. Encoll's phosphorylated collagen renders
unique abilities in the growth of soft or hard tissue
as needed by the physiological system.
Collagen
has become an important tool for hastening the healing
process of injured tissues. Current collagen products
(derived through the extraction or recombinant methods)
have the potential problems in terms of the purity,
immunogenicity and related-problems rendering the collagen
unsuitable for bio-medical and research applications. The
traditional manufacturers of medical grade collagen
and others have agreed that they have considerable amounts
of type-III collagen contamination in their products. This
results in a 3% rejection of their collagen when implanted
in human. Encoll's high purity collagen has proven
to be a superior technology solution for all medical
applications.
EnColl's Competitive Advantage
The
unique post-translational modification (phosphorylation)
of Collagen through EnColl's patented manufacturing
process gives added advantage by enhanced bioactivity
useful for a variety of medical applications.
Other
common benefits of EnColl's collagen (over other commercially
available collagen) in the market are:
- Biocompatibility
- Least
Immunogenicity
- Bioresorbability
- Cell
Attractability
- Hemostastic Ability
- Structural
Stability
- Target
Specificity
- Slow
and Sustained Release of Bound Drugs
- Increased
solubility & Optical clarity at neutral pH after
chemical modification
- Enhanced
bonding to active drugs or factors
- Available
in powder, tubular, gel, film, surface coating, sponge
or in fabric form
- Better
bioactive coating on inactive surfaces.
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